Further evidence about the mechanism of miscarriage – failing to discriminate between healthy and unhealthy embryos

An important new paper has been published in relation to recurrent miscarriage (RM). Weimer et al have shown that there are differences in the migration patterns of endometrial stromal cells in women with and without a history of RM. In controls, the presence of a poor quality embryo was associated with inhibition of stromal migration. In women with a history of recurrent miscarriage this process seems to be deregulated and the endometrium is no longer able to discriminate between normal and abnormal embryos.

This is an important finding. It may add evidence to the view that miscarriage may be dies to a failure to recognise an abnormal embryo – in effect a failure of a natural quality control mechanism. Hence women with RM become pregnant very easily as all embryos implant – but then many pregnancies end in miscarriage due to the higher number of implanted abnormal embryos.

 

 

Professor Tom Bourne

Professor Tom Bourne is Adjunct Professor at Imperial College London, and Consultant Gynaecologist at Queen Charlotte's and Chelsea Hospital. He is also visiting Professor at KU Leuven, Belgium. He has extensive clinical and research experience in early pregnancy care as well as gynaecological ultrasound. He has published over 300 academic papers with an H-index of 63. He advises NICE, is trustee of the ectopic pregnancy trust, President of the UK association of early pregnancy units (AEPU) and on the board of ISUOG. He has a private practice at The Women's Ultrasound Centres at 86 Harley Street and Parkside Hospital in Wimbledon.

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About Professor Tom Bourne

Professor Tom Bourne is Adjunct Professor at Imperial College London, and Consultant Gynaecologist at Queen Charlotte's and Chelsea Hospital. He is also visiting Professor at KU Leuven, Belgium. He has extensive clinical and research experience in early pregnancy care as well as gynaecological ultrasound. He has published over 300 academic papers with an H-index of 63. He advises NICE, is trustee of the ectopic pregnancy trust, President of the UK association of early pregnancy units (AEPU) and on the board of ISUOG. He has a private practice at The Women's Ultrasound Centres at 86 Harley Street and Parkside Hospital in Wimbledon.
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